Joan Wilder, a mousy romance novelist, receives a treasure map in the mail from her recently murdered brother-in-law. Meanwhile, her sister Elaine is kidnapped in Colombia and the two criminals responsible demand that she travel to Colombia to exchange the map for her sister. Joan does, and quickly becomes lost in the jungle after being waylayed by Zolo, a vicious and corrupt Colombian cop who will stop at nothing to obtain the map. There, she meets an irreverent soldier-of-fortune named Jack...

The second part of City Slickers begins after the death of Curly. It is the 40th birthday of Mitch Robbins and the day begins quite good until he returns home (after a hard day at the radio station) and finds his brother Glen, the black sheep of the family, in his sofa. Nevertheless he is about to have a wonderful birthday-night with his wife when he discovers a treasure map of Curly by chance. Together with Phil (from the first part) and unfortunately with Glen he tries to find the hidden gold...